However, most of these BGCs are silent under standard laboratory conditions. Streptomyces have a large number of secondary metabolite biosynthetic gene clusters (SM-BGCs) that may encode NPs. About two-thirds of natural antibiotics are produced by Streptomyces. Natural products (NPs) are critical sources of drug molecules for decades.
2Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin, China.1Key Laboratory of Systems Bioengineering (Ministry of Education), Frontier Science Center for Synthetic Biology, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.Zhenyu Liu 1† Yatong Zhao 1† Chaoqun Huang 1 Yunzi Luo 1,2*
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